Article
A classical likelihood based approach for admixture mapping using EM algorithm.
Human genetics - 1 Oct 2006
Zhu Xiaofeng, Zhang Shuanglin, Tang Hua, Cooper Richard
Abstract excerpt
Several disease-mapping methods have been proposed recently, which use the information generated by recent admixture of populations from historically distinct geographic origins. These methods include both classic likelihood and Bayesian approaches. In this study we directly maximize the likelihood function from the hidden Markov Model for admixture mapping using the EM algorithm, allowing for uncertainty in...
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