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Article

Heterozygosity for Lep(ob) or Lep(rdb) affects body composition and leptin homeostasis in adult mice.

The American journal of physiology - 1 Apr 1998

Chung W K, Belfi K, Chua M, Wiley J, Mackintosh R, Nicolson M, Boozer C N, Leibel R L

Abstract excerpt

In an effort to understand the genetics of human obesity, we have studied the physiology and molecular genetics of rodent models with monogenetic forms of obesity including the leptin gene-defective (Lep(ob)/Lep(ob)) and leptin receptor gene-defective (Lep(rdb)/Lep(rdb)) mouse. In the experiments reported here, we investigated the effects of heterozygosity at Lep(ob) and Lep(rdb) on body composition and...

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Identifiers

PMID: 9575960
DOI: 10.1152/ajpregu.1998.274.4.R985

Genes

LEPR

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