Article
Spontaneous mutation in the db gene results in obesity and diabetes in CD-1 outbred mice.
American journal of physiology. Regulatory, integrative and comparative physiology - 1 Feb 2000
Brown J A, Chua S C, Liu S M, Andrews M T, Vandenbergh J G
Abstract excerpt
Five allelic mutants of the diabetes (db) gene have been previously described in mice and rats causing obesity, infertility, and varying degrees of diabetes. We have identified a new, spontaneous mutation resulting in obesity and diabetes in a colony of CD-1 outbred mice, Mus musculus domesticus. Genetic complementation studies indicated that the new mutation was an allele of the diabetes locus. Sequence analysis...
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