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Article

Contrasting obesity phenotypes uncovered by partial leptin receptor gene deletion in transgenic mice.

Biochemical and biophysical research communications - 16 Mar 2000

Reichart U, Renner-Müller I, Höflich A, Müller O J, Franz W M, Wolf E, Müller M, Brem G, Aigner B

Abstract excerpt

Non-insulin-dependent diabetes mellitus (type 2 diabetes) is known to be a polygenic and polyfactorial disorder. Here we describe the long-term examination of a transgenic mouse line showing the disruption of the leptin receptor (Lepr, Ob-R) gene caused by transgene insertion. The absence of the...

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Source

Identifiers

PMID: 10708583
DOI: 10.1006/bbrc.2000.2318

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-10708583-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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