Article
TP53 mutations in squamous-cell carcinomas of the conjunctiva: evidence for UV-induced mutagenesis.
Mutagenesis - 1 Sept 2004
Ateenyi-Agaba Charles, Dai Min, Le Calvez Florence, Katongole-Mbidde Edward, Smet Anouk, Tommasino Massimo, Franceschi Silvia, Hainaut Pierre, Weiderpass Elisabete
Abstract excerpt
Squamous cell carcinoma of the conjunctiva is associated with sun exposure and often occurs in HIV-positive individuals. We have analysed TP53 mutations in 21 cases of squamous cell carcinoma and 22 controls with benign conjunctival lesions from a region (Uganda, Africa) with a high prevalence of heavy sun exposure and HIV infection. TP53 mutations were detected in 11 cases (52%) and 3 controls (14%). Seven of...
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