Article
Association between ultraviolet-related TP53 mutations and immune microenvironment in equine ocular squamous cell carcinoma.
Scientific reports - 26 Feb 2026
Martinoli Ginevra, De Biase Dario, Ressel Lorenzo, Brunetti Barbara, Avallone Giancarlo, Grillini Alessia, Franceschini Tania, Fiorentino Michelangelo, Sarli Giuseppe, Bacci Barbara
Abstract excerpt
This study investigates the molecular and immune characteristics of equine ocular squamous cell carcinoma (eoSCC). Immunohistochemistry (IHC) and next-generation sequencing (NGS) were used to detect protein expression and TP53 mutations, respectively. T lymphocytes (CD3+), regulatory T cells (FoxP3+), B lymphocytes (CD20+), and macrophages (IBA-1+) were quantified. A total of 29 cases of eoSCC were evaluated,...
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