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Article

The linear effects of alpha-thalassaemia, the UGT1A1 and HMOX1 polymorphisms on cholelithiasis in sickle cell disease.

British journal of haematology - 1 Jul 2007

Vasavda Nisha, Menzel Stephan, Kondaveeti Sheila, Maytham Emma, Awogbade Moji, Bannister Sybil, Cunningham Juliette, Eichholz Andrew, Daniel Yvonne, Okpala Iheanyi, Fulford Tony, Thein Swee Lay

Abstract excerpt

Serum bilirubin levels and predisposition to gallstones in sickle cell disease (SCD) are influenced by genetic variation in the hepatic uridine diphosphate (UDP)-glucuronosyltransferase (UGT1A1) gene, but the association is not consistent. This study investigated whether variation in the gene encoding haem oxygenase (HMOX1), a rate-limiting enzyme upstream of UGT1A in the haem catabolic pathway, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17593033
DOI: 10.1111/j.1365-2141.2007.06643.x

Genes

HMOX1
SCD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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