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Article

Influence of glutathione S-transferase pi and p53 expression on tumor frequency and spectrum in mice.

International journal of cancer - 1 Jan 2005

Gate Laurent, Majumdar Rajrupa S, Lunk Alexandra, Tew Kenneth D

Abstract excerpt

The role of glutathione S-transferase pi (GSTpi) in tumor development has been previously suggested; however the exact function of this enzyme in carcinogenesis remains unclear. GSTpi has been identified as a modulator of cell signaling by interacting with and inhibiting c-Jun N-terminal kinase (JNK). This kinase has been in turn described as a regulator of p53 stability and transcriptional activity. To study the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15386426
DOI: 10.1002/ijc.20540

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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