Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours.

doi:10.1038/356215a0

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours.

Nature - 19 Mar 1992

Donehower L A, Harvey M, Slagle B L, McArthur M J, Montgomery C A, Butel J S, Bradley A

Abstract excerpt

Mutations in the p53 tumour-suppressor gene are the most frequently observed genetic lesions in human cancers. To investigate the role of the p53 gene in mammalian development and tumorigenesis, a null mutation was introduced into the gene by homologous recombination in murine embryonic stem cells. Mice homozygous for the null allele appear normal but are prone to the spontaneous development of a variety of...

Topics

Alleles
Animals
Base Sequence
Blastocyst
Blotting, Southern
DNA
Exons
Female
Genes, p53
Genetic Vectors
Heterozygote
Homozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mice

Mice, Inbred C57BL

Mice, Inbred CBA

Mice, Transgenic

Molecular Sequence Data

Source

Open in PubMed

Identifiers

PMID: 1552940
DOI: 10.1038/356215a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1552940-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours.PMID 1552940Read ↗

Analysing p53 tumour suppressor functions in mice.Semantic proximity Read ↗

Development of novel mouse models to study the p53 tumour suppressorSemantic proximity Read ↗

Generation and characterization of p53 mutant mice.Semantic proximity Read ↗

Tumour incidence, spectrum and ploidy in mice with a large deletion in the p53 gene.Semantic proximity Read ↗

Rats deficient for p53 are susceptible to spontaneous and carcinogen-induced tumorigenesis.Semantic proximity Read ↗

Genetic background alters the spectrum of tumors that develop in p53‐deficient miceSemantic proximity Read ↗

p63 heterozygous mutant mice are not prone to spontaneous or chemically induced tumors.Semantic proximity Read ↗

Effects of genetic background on tumorigenesis in p53-deficient mice.Semantic proximity Read ↗

Tumor spectrum analysis in p53-mutant mice.Semantic proximity Read ↗

The mutant p53 mouse as a pre-clinical model.Semantic proximity Read ↗

Probing p53 biological functions through the use of genetically engineered mouse models.Semantic proximity Read ↗

The p53 pathway in hematopoiesis: lessons from mouse models, implications for humansSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.