Article
Multi-copy suppression of an Aspergillus nidulans mutant sensitive to camptothecin by a putative monocarboxylate transporter.
Current microbiology - 1 Oct 2004
Semighini Camile P, Goldman Maria Helena S, Goldman Gustavo Henrique
Abstract excerpt
The Mono carboxylate Transporter (MCT) is a family of membrane proteins from the Major Facilitator Superfamily (MFS) of transporters. Here, we report the first identified Aspergillus nidulans MCT homologue, AmcA. The amcA gene was isolated by high copy number suppression of the hydroxyurea (HU) sensitivity of an A. nidulans camptothecin-sensitive mutant. Expression of amcA is increased when hyphae are grown in...
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