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Article

Putative orotate transporter of Cryptococcus neoformans, Oat1, is a member of the NCS1/PRT transporter super family and its loss causes attenuation of virulence.

Current genetics - 1 Aug 2017

Toh-E Akio, Ohkusu Misako, Shimizu Kiminori, Takahashi-Nakaguchi Azusa, Kawamoto Susumu, Ishiwada Naruhiko, Watanabe Akira, Kamei Katsuhiko

Abstract excerpt

It is well known that 5-fluoroorotic acid (5-FOA)-resistant mutants isolated from wild-type Cryptococcus neoformans are exclusively either ura3 or ura5 mutants. Unexpectedly, many of the 5-FOA-resistant mutants isolated in our selective regime were Ura+. We identified CNM00460 as the gene responsible for these mutations. Cnm00460 belongs to the nucleobase cation symporter 1/purine-related transporter (NCS1/PRT)...

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Source

Identifiers

PMID: 28011993
DOI: 10.1007/s00294-016-0672-5

Genes

NCS1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Putative orotate transporter of Cryptococcus neoformans, Oat1, is a member of the NCS1/PRT transporter super family and its loss causes attenuation of virulence.PMID 28011993Read ↗

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