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Article

Tropism switching in Bordetella bacteriophage defines a family of diversity-generating retroelements.

Nature - 23 Sept 2004

Doulatov Sergei, Hodes Asher, Dai Lixin, Mandhana Neeraj, Liu Minghsun, Deora Rajendar, Simons Robert W, Zimmerly Steven, Miller Jeff F

Abstract excerpt

Bordetella bacteriophages generate diversity in a gene that specifies host tropism. This microevolutionary adaptation is produced by a genetic element that combines the basic retroelement life cycle of transcription, reverse transcription and integration with site-directed, adenine-specific mutagenesis. Central to this process is a reverse transcriptase-mediated exchange between two repeats; one serving as a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15386016
DOI: 10.1038/nature02833

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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