Article
Template-assisted synthesis of adenine-mutagenized cDNA by a retroelement protein complex.
Nucleic acids research - 12 Oct 2018
Handa Sumit, Jiang Yong, Tao Sijia, Foreman Robert, Schinazi Raymond F, Miller Jeff F, Ghosh Partho
Abstract excerpt
Diversity-generating retroelements (DGRs) create unparalleled levels of protein sequence variation through mutagenic retrohoming. Sequence information is transferred from an invariant template region (TR), through an RNA intermediate, to a protein-coding variable region. Selective infidelity at adenines during transfer is a hallmark of DGRs from disparate bacteria, archaea, and microbial viruses. We recapitulated...
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