Article
Reverse transcriptase-mediated tropism switching in Bordetella bacteriophage.
Science (New York, N.Y.) - 15 Mar 2002
Liu Minghsun, Deora Rajendar, Doulatov Sergei R, Gingery Mari, Eiserling Frederick A, Preston Andrew, Maskell Duncan J, Simons Robert W, Cotter Peggy A, Parkhill Julian, Miller Jeff F
Abstract excerpt
Host-pathogen interactions are often driven by mechanisms that promote genetic variability. We have identified a group of temperate bacteriophages that generate diversity in a gene, designated mtd (major tropism determinant), which specifies tropism for receptor molecules on host Bordetella species. Tropism switching is the result of a template-dependent, reverse transcriptase-mediated process that introduces...
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