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Article

Early embryonic lethality in gene trap mice with disruption of the Arfgef2 gene.

The International journal of developmental biology - 1 Jan 2010

Grzmil Pawel, Enkhbaatar Zanabazar, Gundsambuu Batjargal, Oidovsambuu Odgerel, Yalcin Safak, Wolf Stephan, Engel Wolfgang, Neesen Jurgen

Abstract excerpt

The switching of ADP-ribosylation factors from the inactive form to the active form is catalyzed by ARF-GEF (ADP ribosylation factor--guanine nucleotide exchange protein) proteins containing a Sec7 domain. The murine Arfgef2 gene encoding the BIG2 protein belongs to the class of high molecular ma...

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Source

Identifiers

PMID: 20857375
DOI: 10.1387/ijdb.092959pg

Genes

ARFGEF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20857375-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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