Article
Mutations in ARFGEF2 implicate vesicle trafficking in neural progenitor proliferation and migration in the human cerebral cortex.
Nature genetics - 1 Jan 2004
Sheen Volney L, Ganesh Vijay S, Topcu Meral, Sebire Guillaume, Bodell Adria, Hill R Sean, Grant P Ellen, Shugart Yin Yao, Imitola Jaime, Khoury Samia J, Guerrini Renzo, Walsh Christopher A
Abstract excerpt
Disruption of human neural precursor proliferation can give rise to a small brain (microcephaly), and failure of neurons to migrate properly can lead to an abnormal arrest of cerebral cortical neurons in proliferative zones near the lateral ventricles (periventricular heterotopia). Here we show t...
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