Article
The Gly-Gly linker region of the insect cytokine growth-blocking peptide is essential for activity.
The Journal of biological chemistry - 3 Dec 2004
Yoshida Masanobu, Aizawa Tomoyasu, Nakamura Takashi, Shitara Kunio, Hayakawa Yoichi, Matsubara Kimiaki, Miura Kazunori, Kouno Takahide, Clark Kevin D, Strand Michael R, Mizuguchi Mineyuki, Demura Makoto, Nitta Katsutoshi, Kawano Keiichi
Abstract excerpt
Growth-blocking peptide (GBP) is a 25-amino acid cytokine isolated from the lepidopteran insect Pseudaletia separata. GBP exhibits various biological activities such as regulation of larval growth of insects, proliferation of a few kinds of cultured cells, and stimulation of a class of insect immune cells called plasmatocytes. The tertiary structure of GBP consists of a well structured core domain and disordered...
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