Article
N-terminal residues of plasmatocyte-spreading peptide possess specific determinants required for biological activity.
The Journal of biological chemistry - 5 Oct 2001
Clark K D, Volkman B F, Thoetkiattikul H, Hayakawa Y, Strand M R
Abstract excerpt
Plasmatocyte-spreading peptide (PSP) is a 23-amino acid cytokine that activates a class of insect immune cells called plasmatocytes. The tertiary structure of PSP consists of an unstructured N terminus (residues 1-6) and a well structured core (residues 7-23). A prior study indicated that deletion of the N terminus from PSP eliminated all biological activity. Alanine substitution of the first three residues...
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