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Article

Specific residues in plasmatocyte-spreading peptide are required for receptor binding and functional antagonism of insect immune cells.

The Journal of biological chemistry - 6 Aug 2004

Clark Kevin D, Garczynski Stephen F, Arora Aditi, Crim Joe W, Strand Michael R

Abstract excerpt

Plasmatocyte-spreading peptide (PSP) is a 23-amino acid cytokine that activates a class of insect immune cells called plasmatocytes. PSP consists of two regions: an unstructured N terminus (1-6) and a highly structured core (7-23). Prior studies identified specific residues in both the structured and unstructured regions required for biological activity. Most important for function were Arg13, Phe3, Cys7, Cys19,...

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Identifiers

PMID: 15192108
DOI: 10.1074/jbc.M401157200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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