Article
Mapping the region of the alpha-type phospholipase A2 inhibitor responsible for its inhibitory activity.
The Journal of biological chemistry - 11 Nov 2005
Okumura Kohji, Ohno Ai, Nishida Masanori, Hayashi Kyozo, Ikeda Kiyoshi, Inoue Seiji
Abstract excerpt
alpha-Type phospholipase A(2) inhibitory protein (PLIalpha) from the serum of the venomous snake Gloydius brevicaudus, GbPLIalpha,isone of the protective endogenous proteins that neutralizes its own venom phospholipase A(2) (PLA(2)), and it is a homotrimer of subunits having a C-type lectin-like domain. The nonvenomous snake Elaphe quadrivirgata has a homologous serum protein, EqPLIalpha-LP, that does not show...
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