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Article

Sterol-derived hormone(s) controls entry into diapause in Caenorhabditis elegans by consecutive activation of DAF-12 and DAF-16.

PLoS biology - 1 Oct 2004

Matyash Vitali, Entchev Eugeni V, Mende Fanny, Wilsch-Bräuninger Michaela, Thiele Christoph, Schmidt Arndt W, Knölker Hans-Joachim, Ward Samuel, Kurzchalia Teymuras V

Abstract excerpt

Upon starvation or overcrowding, Caenorhabditis elegans interrupts its reproductive cycle and forms a specialised larva called dauer (enduring). This process is regulated by TGF-beta and insulin-signalling pathways and is connected with the control of life span through the insulin pathway components DAF-2 and DAF-16. We found that replacing cholesterol with its methylated metabolite lophenol induced worms to form...

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Identifiers

PMID: 15383841
DOI: 10.1371/journal.pbio.0020280
PMCID: PMC517820

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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