Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A hormonal signaling pathway influencing C. elegans metabolism, reproductive development, and life span.

Developmental cell - 1 Dec 2001

Gerisch B, Weitzel C, Kober-Eisermann C, Rottiers V, Antebi A

Abstract excerpt

During C. elegans development, animals must choose between reproductive growth or dauer diapause in response to sensory cues. Insulin/IGF-I and TGF-beta signaling converge on the orphan nuclear receptor daf-12 to mediate this choice. Here we show that daf-9 acts downstream of these inputs but ups...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue
Share to Caenorhabditis elegans Proteins
Share to Cholesterol

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Insulin-Like Growth Factor I

Share to Longevity

Share to Receptors, Cytoplasmic and Nuclear

Share to Tissue Distribution

Share to Transforming Growth Factor beta

Source

Identifiers

PMID: 11740945
DOI: 10.1016/s1534-5807(01)00085-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11740945-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A hormonal signaling pathway influencing C. elegans metabolism, reproductive development, and life span.PMID 11740945Read ↗

DAF-9, a cytochrome P450 regulating C. elegans larval development and adult longevity.Semantic proximity Read ↗

Hormonal control of C. elegans dauer formation and life span by a Rieske-like oxygenase.Semantic proximity Read ↗

Lipophilic regulator of a developmental switch in Caenorhabditis elegans.Semantic proximity Read ↗

A steroid hormone that extends the lifespan of Caenorhabditis elegans.Semantic proximity Read ↗

Intercellular signaling of reproductive development by the C. elegans DAF-9 cytochrome P450.Semantic proximity Read ↗

Indicted: worms caught using steroids.Semantic proximity Read ↗

daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans.Semantic proximity Read ↗

DAF-12-dependent rescue of dauer formation in Caenorhabditis elegans by (25S)-cholestenoic acid.Semantic proximity Read ↗

Histone H3K4me3 modification is a transgenerational epigenetic signal for lipid metabolism in Caenorhabditis elegansSemantic proximity Read ↗

Comparative metabolomics reveals endogenous ligands of DAF-12, a nuclear hormone receptor, regulating C. elegans development and lifespan.Semantic proximity Read ↗

A novel nuclear receptor/coregulator complex controls C. elegans lipid metabolism, larval development, and aging.Semantic proximity Read ↗

Influence of steroid hormone signaling on life span control by Caenorhabditis elegans insulin-like signaling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.