Article
Endocannabinoids in Caenorhabditis elegans are essential for the mobilization of cholesterol from internal reserves.
Scientific reports - 23 Apr 2018
Galles Celina, Prez Gastón M, Penkov Sider, Boland Sebastian, Porta Exequiel O J, Altabe Silvia G, Labadie Guillermo R, Schmidt Ulrike, Knölker Hans-Joachim, Kurzchalia Teymuras V, de Mendoza Diego
Abstract excerpt
Proper cholesterol transport is crucial for the functionality of cells. In C. elegans, certain cholesterol derivatives called dafachronic acids (DAs) govern the entry into diapause. In their absence, worms form a developmentally arrested dauer larva. Thus, cholesterol transport to appropriate places for DA biosynthesis warrants the reproductive growth. Recently, we discovered a novel class of glycosphingolipids,...
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