Article
Association analysis for the muscarinic M1 receptor genetic polymorphisms and Alzheimer's disease.
Dementia and geriatric cognitive disorders - 1 Jan 2005
Liu Hsiu-Chih, Hong Chen-Jee, Liu Tsung-Yun, Chi Chin-Wen, Tsai Shih-Jen
Abstract excerpt
In the ongoing search to reveal the pathophysiology of Alzheimer's disease (AD), the cholinergic system is important due to its role in cognitive function and its significance with respect to the results of postmortem pathology and animal model studies. For this investigation, we tested the hypothesis that the allelic variant (C267A) of the cholinergic receptor muscarinic 1 (CHRM1) confers susceptibility to AD or...
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