Article
Functional screening of drug target genes: m1 muscarinic acetylcholine receptor phenotypes in degenerative dementias.
American journal of pharmacogenomics : genomics-related research in drug development and clinical practice - 1 Jan 2004
Weiner David M, Goodman Matilda W, Colpitts Tonya M, Feddock Michelle A, Duggento Kate L, Nash Norman R, Levey Allan I, Brann Mark R
Abstract excerpt
BACKGROUND AND OBJECTIVES: A number of recent studies surveying single nucleotide polymorphisms within the exonic regions of human genes have revealed a significant number of such variants, including many non-synonymous variants. This highlights the need to directly identify, within individual clinically well-defined patients, those variants that alter protein function as well as structure. We report on the...
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