Article
Lack of implication for CALHM1 P86L common variation in Italian patients with early and late onset Alzheimer's disease.
Journal of Alzheimer's disease : JAD - 1 Jan 2010
Nacmias Benedetta, Tedde Andrea, Bagnoli Silvia, Lucenteforte Ersilia, Cellini Elena, Piaceri Irene, Guarnieri Bianca Maria, Bessi Valentina, Bracco Laura, Sorbi Sandro
Abstract excerpt
A recent study identified a polymorphism (Pro86Leu) in the Calcium homeostasis modulator 1 (CALHM1) gene whose minor Leucine allele showed a higher frequency in Alzheimer's disease (AD) patients compared to controls (29% in AD and 22% in controls). Further studies provided conflicting results in different ethnic groups. In order to assess the involvement of the CALHM1 genetic variant on the risk of developing AD,...
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