Article
The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study.
Journal of Alzheimer's disease : JAD - 1 Jan 2010
Lambert Jean-Charles, Sleegers Kristel, González-Pérez Antonio, Ingelsson Martin, Beecham Gary W, Hiltunen Mikko, Combarros Onofre, Bullido Maria J, Brouwers Nathalie, Bettens Karolien, Berr Claudine, Pasquier Florence, Richard Florence, Dekosky Steven T, Hannequin Didier, Haines Jonathan L, Tognoni Gloria, Fiévet Nathalie, Dartigues Jean-François, Tzourio Christophe, Engelborghs Sebastiaan, Arosio Beatrice, Coto Elicer, De Deyn Peter, Del Zompo Maria, Mateo Ignacio, Boada Merce, Antunez Carmen, Lopez-Arrieta Jesus, Epelbaum Jacques, Schjeide Brit-Maren Michaud, Frank-Garcia Ana, Giedraitis Vilmentas, Helisalmi Seppo, Porcellini Elisa, Pilotto Alberto, Forti Paola, Ferri Raffaele, Delepine Marc, Zelenika Diana, Lathrop Mark, Scarpini Elio, Siciliano Gabriele, Solfrizzi Vincenzo, Sorbi Sandro, Spalletta Gianfranco, Ravaglia Giovanni, Valdivieso Fernando, Vepsäläinen Saila, Alvarez Victoria, Bosco Paolo, Mancuso Michelangelo, Panza Francesco, Nacmias Benedetta, Bossù Paola, Hanon Olivier, Piccardi Paola, Annoni Giorgio, Mann David, Marambaud Philippe, Seripa Davide, Galimberti Daniela, Tanzi Rudolph E, Bertram Lars, Lendon Corinne, Lannfelt Lars, Licastro Federico, Campion Dominique, Pericak-Vance Margaret A, Soininen Hilkka, Van Broeckhoven Christine, Alpérovitch Annick, Ruiz Agustin, Kamboh M Ilyas, Amouyel Philippe
Abstract excerpt
The only established genetic determinant of non-Mendelian forms of Alzheimer's disease (AD) is the ε4 allele of the apolipoprotein E gene (APOE). Recently, it has been reported that the P86L polymorphism of the calcium homeostasis modulator 1 gene (CALHM1) is associated with the risk of developing AD. In order to independently assess this association, we performed a meta-analysis of 7,873 AD cases and 13,274...
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