Differential analysis of CD4+ Th memory clones with identical T-cell receptor (TCR)-alphabeta rearrangement (non-transgenic), but distinct lymphokine phenotype, reveals diverse and novel gene expression.

Abstract excerpt

This study describes a subtractive hybridization analysis to identify differences in gene expression between sibling Th memory clones, elicited by virus infection and expressing identical T-cell receptor (TCR)-alphabeta rearrangements but distinct lymphokine phenotype: clone Bpp9 secretes interleukin (IL)-4, IL-5 and IL-10; clone Bpp19 secretes interferon (IFN)-gamma, low levels of IL-4, and IL-5 on TCR ligation....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor
• Share to Immunologic Memory