Article
The transcriptional regulator PLZF induces the development of CD44 high memory phenotype T cells.
Proceedings of the National Academy of Sciences of the United States of America - 18 Nov 2008
Raberger Julia, Schebesta Alexandra, Sakaguchi Shinya, Boucheron Nicole, Blomberg K Emelie M, Berglöf Anna, Kolbe Thomas, Smith C I Edvard, Rülicke Thomas, Ellmeier Wilfried
Abstract excerpt
Transcriptional pathways controlling the development of CD44(hi) memory phenotype (MP) T cells with "innate-like" functions are not well understood. Here we show that the BTB (bric-a-brac, tramtrack, broad complex) domain-containing protein promyelocytic leukemia zinc finger (PLZF) is expressed in CD44(hi), but not in CD44(lo), CD4(+) T cells. Transgenic expression of PLZF during T cell development and in CD4(+)...
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