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Article

Insulin‐like 3 signalling in testicular descent

17 Sept 2004

Abstract excerpt

Undescended testis is one of the most common congenital defects in the newborn boys and the common cause of cryptorchidism. If left untreated, this condition is strongly associated with infertility and drastically increased risk of testicular cancer in adulthood. Testis position in developing males is defined by sexual dimorphic differentiation of two gonadal ligaments, gubernaculum and cranial suspensory...

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Identifiers

PMID: 15379965
DOI: 10.1111/j.1365-2605.2004.00481.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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Insulin‐like 3 signalling in testicular descentPMID 15379965Read ↗

INSL3/LGR8 role in testicular descent and cryptorchidism.Semantic proximity Read ↗

Cryptorchidism in mice mutant for Insl3.Semantic proximity Read ↗

GREAT/LGR8 is the only receptor for insulin-like 3 peptide.Semantic proximity Read ↗

Targeted disruption of the Insl3 gene causes bilateral cryptorchidism.Semantic proximity Read ↗

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Suppression of Insulin-Like3 Receptor Reveals the Role of β-Catenin and Notch Signaling in Gubernaculum DevelopmentSemantic proximity Read ↗

Insulin-Like 3 Signaling Is Important for Testicular Descent but Dispensable for Spermatogenesis and Germ Cell Survival in Adult Mice1Semantic proximity Read ↗

Insulin-like 3/relaxin-like factor gene mutations are associated with cryptorchidism.Semantic proximity Read ↗

Leydig insulin-like hormone, gubernacular development and testicular descent.Semantic proximity Read ↗

Role of INSL3 and LGR8 in cryptorchidism and testicular functions.Semantic proximity Read ↗

INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent.Semantic proximity Read ↗

The molecular basis of cryptorchidism.Semantic proximity Read ↗

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