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Article

Targeted disruption of the Insl3 gene causes bilateral cryptorchidism.

Molecular endocrinology (Baltimore, Md.) - 1 May 1999

Zimmermann S, Steding G, Emmen J M, Brinkmann A O, Nayernia K, Holstein A F, Engel W, Adham I M

Abstract excerpt

The sexual dimorphic position of the gonads in mammals is dependent on differential development of two ligaments, the cranial suspensory ligament (CSL) and the gubernaculum. During male embryogenesis, outgrowth of the gubernaculum and regression of the CSL result in transabdominal descent of the testes, whereas in the female, development of the CSL in conjunction with failure of the gubernaculum development holds...

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Source

Identifiers

PMID: 10319319
DOI: 10.1210/mend.13.5.0272

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Targeted disruption of the Insl3 gene causes bilateral cryptorchidism.PMID 10319319Read ↗

Cryptorchidism in mice mutant for Insl3.Semantic proximity Read ↗

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The Overexpression of the<i>Insl3</i>in Female Mice Causes Descent of the OvariesSemantic proximity Read ↗

Suppression of Insulin-Like3 Receptor Reveals the Role of β-Catenin and Notch Signaling in Gubernaculum DevelopmentSemantic proximity Read ↗

Insulin‐like 3 signalling in testicular descentSemantic proximity Read ↗

Leydig insulin-like hormone, gubernacular development and testicular descent.Semantic proximity Read ↗

INSL3/RXFP2 Signaling in Testicular DescentSemantic proximity Read ↗

Transabdominal testicular descent is disrupted in mice with deletion of insulinlike factor 3 receptor.Semantic proximity Read ↗

Targeted Disruption of the Insl3 Gene Causes Bilateral CryptorchidismSemantic proximity Read ↗

Cryptorchidism in the orl rat is associated with muscle patterning defects in the fetal gubernaculum and altered hormonal signaling.Semantic proximity Read ↗

The molecular basis of cryptorchidism.Semantic proximity Read ↗

INSL3/LGR8 role in testicular descent and cryptorchidism.Semantic proximity Read ↗

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