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Article

Cryptorchidism in mice mutant for Insl3.

Nature genetics - 1 Jul 1999

Nef S, Parada L F

Abstract excerpt

Impaired testicular descent (cryptorchidism) is one of the most frequent congenital abnormalities in humans, involving 2% of male births. Cryptorchidism can result in infertility and increases risk for development of germ-cell tumours. Testicular descent from abdomen to scrotum occurs in two distinct phases: the trans-abdominal phase and the inguino-scrotal phase. Currently, little is known about the factors that...

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PMID: 10391220
DOI: 10.1038/10364

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence.

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Cryptorchidism in mice mutant for Insl3.PMID 10391220Read ↗

Targeted disruption of the Insl3 gene causes bilateral cryptorchidism.Semantic proximity Read ↗

Loss of Insl3: a potential predisposing factor for testicular torsion.Semantic proximity Read ↗

Insulin‐like 3 signalling in testicular descentSemantic proximity Read ↗

INSL3/LGR8 role in testicular descent and cryptorchidism.Semantic proximity Read ↗

INSL3/RXFP2 Signaling in Testicular DescentSemantic proximity Read ↗

Suppression of Insulin-Like3 Receptor Reveals the Role of β-Catenin and Notch Signaling in Gubernaculum DevelopmentSemantic proximity Read ↗

Targeted Disruption of the Insl3 Gene Causes Bilateral CryptorchidismSemantic proximity Read ↗

The molecular basis of cryptorchidism.Semantic proximity Read ↗

Insulin-like 3/relaxin-like factor gene mutations are associated with cryptorchidism.Semantic proximity Read ↗

The Overexpression of the<i>Insl3</i>in Female Mice Causes Descent of the OvariesSemantic proximity Read ↗

GREAT/LGR8 is the only receptor for insulin-like 3 peptide.Semantic proximity Read ↗

Novel mutations involving the INSL3 gene associated with cryptorchidism.Semantic proximity Read ↗

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