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Article

Leydig insulin-like hormone, gubernacular development and testicular descent.

The Journal of urology - 1 May 2001

Kubota Y, Nef S, Farmer P J, Temelcos C, Parada L F, Hutson J M

Abstract excerpt

PURPOSE: Testicular descent is controlled by 2 morphological and hormonal steps. Transabdominal testicular descent is mediated by gubernacular swelling and regression of the cranial suspensory ligament. Müllerian inhibiting substance (MIS) has been proposed to stimulate the swelling but this remains controversial. Recently, a mouse mutant for Leydig insulin-like hormone (Insl3) was found to have undescended...

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PMID: 11342953

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Leydig insulin-like hormone, gubernacular development and testicular descent.PMID 11342953Read ↗

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Insulin-Like 3 Signaling Is Important for Testicular Descent but Dispensable for Spermatogenesis and Germ Cell Survival in Adult Mice1Semantic proximity Read ↗

Suppression of Insulin-Like3 Receptor Reveals the Role of β-Catenin and Notch Signaling in Gubernaculum DevelopmentSemantic proximity Read ↗

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INSL3/LGR8 role in testicular descent and cryptorchidism.Semantic proximity Read ↗

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