Article
The antibiotic selective process: concentration-specific amplification of low-level resistant populations.
Ciba Foundation symposium - 1 Jan 1997
Baquero F, Negri M C, Morosini M I, Blázquez J
Abstract excerpt
The biochemistry and genetics of antibiotic resistance are far better known than the equally important events underlying the selection of resistant populations. The hidden selection of low-level resistant variants may be a key process in the emergence of high-level antibiotic resistance. Different low-level resistant bacterial subpopulations may be specifically selected by different low antibiotic concentrations....
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