Article
Genetic variants of the sulfotransferase 1A1 and breast cancer risk.
Breast cancer research and treatment - 1 Sept 2004
Langsenlehner Uwe, Krippl Peter, Renner Wilfried, Yazdani-Biuki Babak, Eder Tanja, Wolf Gerald, Wascher Thomas C, Paulweber Bernhard, Weitzer Werner, Samonigg Hellmut
Abstract excerpt
Sulfotransferase 1A1 (SULT1A1), also designated as phenol-preferring sulfotransferase, is involved in the bioactivation and detoxification of a variety of potential carcinogens, including iodothyronines, hydroxylated aromatic amines, and phenolic xenobiotics. A common arginine (R) to histidine (H) polymorphism at amino acid position 213 influences SULT1A1 activity and has been suggested as risk factor for a...
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