Article
A case-control study investigating the role of sulfotransferase 1A1 polymorphism in head and neck cancer.
Journal of cancer research and clinical oncology - 1 Jul 2006
Boccia Stefania, Cadoni Gabriella, La Torre Giuseppe, Arzani Dario, Volante Mariangela, Cattel Caterina, Gianfagna Francesco, Paludetti Gaetano, Almadori Giovanni, Ricciardi Gualtiero
Abstract excerpt
PURPOSE: Sulfotransferases (SULT) 1A1 detoxify and bio-activate a broad spectrum of substrates including xenobiotics. The SULT1A1 gene possesses a G-->A polymorphism that results in an Arg to His substitution at codon 213, with the His allele having a low activity. The purpose of this study was to evaluate whether SULT1A1 Arg213His polymorphisms are risk factors for head and neck squamous cell carcinoma (SCCHN)....
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