Article
Modifying effects of sulfotransferase 1A1 gene polymorphism on the association of breast cancer risk with body mass index or endogenous steroid hormones.
Breast cancer research and treatment - 1 Nov 2005
Yang Gong, Gao Yu-Tang, Cai Qiu-Yin, Shu Xiao-Ou, Cheng Jia-Rong, Zheng Wei
Abstract excerpt
Sulfotransferase (SULT) 1A1 is involved in the inactivation and elimination of estrogens and catechol estrogens. A common functional polymorphism (Arg213His) has been linked in our previous study of postmenopausal Caucasian women to an elevated risk of breast cancer and the association appeared to be modified by factors related to high endogenous estrogen exposures. We further evaluated this polymorphism and...
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