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Article

Increased constitutive activity of PKB/Akt in tamoxifen resistant breast cancer MCF-7 cells.

Breast cancer research and treatment - 1 Sept 2004

Jordan Nicola J, Gee Julia M W, Barrow Denise, Wakeling Alan E, Nicholson Robert I

Abstract excerpt

The tamoxifen-resistant (TAM-R) MCF-7 breast cancer cell line has been used as a model to identify the signalling pathways that enable resistant cancer cells to grow independently of steroid hormones. In TAM-R cells, peptide growth factor signalling pathways appear to be important in modified cell behaviour, growth and survival. The PI3 kinase signalling components Akt1 and Akt2 are expressed at similar levels by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15377841
DOI: 10.1023/B:BREA.0000041623.21338.47

Genes

EGF
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Increased constitutive activity of PKB/Akt in tamoxifen resistant breast cancer MCF-7 cells.PMID 15377841Read ↗

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