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Article

HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells.

Oncogene - 22 May 2003

Knuefermann Christiane, Lu Yang, Liu Bolin, Jin Weidong, Liang Ke, Wu Ling, Schmidt Mathias, Mills Gordon B, Mendelsohn John, Fan Zhen

Abstract excerpt

Growth factor receptor-mediated signal transduction has been implicated in conferring resistance to conventional chemotherapy on cancer cells. In this study, we delineated a pathway that involves HER2/PI-3K/Akt in mediating multidrug resistance in human breast cancer cells. We found that the cell lines that express both HER2 and HER3 appear to have a higher phosphorylation level of Akt (activated Akt)....

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-akt

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Source

Identifiers

PMID: 12761490
DOI: 10.1038/sj.onc.1206394

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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