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Article

A role for Akt in mediating the estrogenic functions of epidermal growth factor and insulin-like growth factor I.

Endocrinology - 1 Dec 2000

Martin M B, Franke T F, Stoica G E, Chambon P, Katzenellenbogen B S, Stoica B A, McLemore M S, Olivo S E, Stoica A

Abstract excerpt

This study examines whether the serine/threonine protein kinase, Akt, is involved in the cross-talk between epidermal growth factor (EGF) and insulin-related growth factor I (IGF-I) receptors and ER-alpha. Treatment of MCF-7 cells with either EGF or IGF-I resulted in a rapid phosphorylation of Akt and a 14- to 16-fold increase in Akt activity, respectively. Akt activation was blocked by inhibitors of...

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Share to Epidermal Growth Factor
Share to Estrogen Receptor alpha

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Insulin-Like Growth Factor I

Share to Phosphoinositide-3 Kinase Inhibitors

Share to Proto-Oncogene Proteins c-akt

Share to Receptors, Estrogen

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Source

Identifiers

PMID: 11108261
DOI: 10.1210/endo.141.12.7836

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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