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Article

PI3K/Akt-sensitive MEK-independent compensatory circuit of ERK activation in ER-positive PI3K-mutant T47D breast cancer cells.

Cellular signalling - 1 Sept 2010

Aksamitiene Edita, Kholodenko Boris N, Kolch Walter, Hoek Jan B, Kiyatkin Anatoly

Abstract excerpt

We explored the crosstalk between cell survival (phosphatidylinositol 3-kinase (PI3K)/Akt) and mitogenic (Ras/Raf/MEK/extracellular signal-regulated kinase (ERK)) signaling pathways activated by an epidermal growth factor (EGF) and analyzed their sensitivity to small molecule inhibitors in the PI3K-mutant estrogen receptor (ER)-positive MCF7 and T47D breast cancer cells. In contrast to MCF7 cells, ERK...

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Share to Carcinoma, Ductal, Breast
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Extracellular Signal-Regulated MAP Kinases

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Source

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Identifiers

PMID: 20471474
DOI: 10.1016/j.cellsig.2010.05.006
PMCID: PMC2893265

Genes

EGF
PBK
PDK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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