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Article

Polarity and proliferation are controlled by distinct signaling pathways downstream of PI3-kinase in breast epithelial tumor cells.

The Journal of cell biology - 16 Feb 2004

Liu Hong, Radisky Derek C, Wang Fei, Bissell Mina J

Abstract excerpt

Loss of tissue polarity and increased proliferation are the characteristic alterations of the breast tumor phenotype. To investigate these processes, we used a three-dimensional (3D) culture system in which malignant human breast cells can be reverted to a normal phenotype by exposure to inhibito...

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Identifiers

PMID: 14769856
DOI: 10.1083/jcb.200306090
PMCID: PMC2171976

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PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14769856-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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