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Article

Secretion and assembly of type IV and VI collagens depend on glycosylation of hydroxylysines.

The Journal of biological chemistry - 16 Nov 2007

Sipilä Laura, Ruotsalainen Heli, Sormunen Raija, Baker Naomi L, Lamandé Shireen R, Vapola Miia, Wang Chunguang, Sado Yoshikazu, Aszodi Attila, Myllylä Raili

Abstract excerpt

Most lysines in type IV and VI collagens are hydroxylated and glycosylated, but the functions of these unique galactosylhydroxylysyl and glucosylgalactosylhydroxylysyl residues are poorly understood. The formation of glycosylated hydroxylysines is catalyzed by multifunctional lysyl hydroxylase 3 (LH3) in vivo, and we have used LH3-manipulated mice and cells as models to study the function of these carbohydrates....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 17873278
DOI: 10.1074/jbc.M704198200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Secretion and assembly of type IV and VI collagens depend on glycosylation of hydroxylysines.PMID 17873278Read ↗

Glycosylation catalyzed by lysyl hydroxylase 3 is essential for basement membranes.Semantic proximity Read ↗

Premature aggregation of type IV collagen and early lethality in lysyl hydroxylase 3 null mice.Semantic proximity Read ↗

Regulation of post-Golgi LH3 trafficking is essential for collagen homeostasis.Semantic proximity Read ↗

The third activity for lysyl hydroxylase 3: galactosylation of hydroxylysyl residues in collagens in vitro.Semantic proximity Read ↗

Re-evaluation of lysyl hydroxylation in the collagen triple helix: lysyl hydroxylase 1 and prolyl 3-hydroxylase 3 have site-differential and collagen type-dependent roles in lysine hydroxylationSemantic proximity Read ↗

Reduction of lysyl hydroxylase 3 causes deleterious changes in the deposition and organization of extracellular matrix.Semantic proximity Read ↗

Biological role of prolyl 3-hydroxylation in type IV collagen.Semantic proximity Read ↗

Molecular architecture of the multifunctional collagen lysyl hydroxylase and glycosyltransferase LH3.Semantic proximity Read ↗

A connective tissue disorder caused by mutations of the lysyl hydroxylase 3 gene.Semantic proximity Read ↗

Lysyl hydroxylase 3 is secreted from cells by two pathways.Semantic proximity Read ↗

Lysyl hydroxylase 3 modifies lysine residues to facilitate oligomerization of mannan-binding lectin.Semantic proximity Read ↗

Lysyl hydroxylase 3 is required for normal lens capsule formation and maintenance of lens epithelium integrity and fate.Semantic proximity Read ↗

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