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Article

Glycosylation catalyzed by lysyl hydroxylase 3 is essential for basement membranes.

Journal of cell science - 15 Feb 2006

Ruotsalainen Heli, Sipilä Laura, Vapola Miia, Sormunen Raija, Salo Antti M, Uitto Lahja, Mercer Derry K, Robins Simon P, Risteli Maija, Aszodi Attila, Fässler Reinhard, Myllylä Raili

Abstract excerpt

Lysyl hydroxylase 3 (LH3) is a multifunctional enzyme possessing lysyl hydroxylase (LH), hydroxylysyl galactosyltransferase (GT) and galactosylhydroxylysyl glucosyltransferase (GGT) activities in vitro. To investigate the in vivo importance of LH3-catalyzed lysine hydroxylation and hydroxylysine-...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16467571
DOI: 10.1242/jcs.02780

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16467571-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Glycosylation catalyzed by lysyl hydroxylase 3 is essential for basement membranes.PMID 16467571Read ↗

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Secretion and assembly of type IV and VI collagens depend on glycosylation of hydroxylysines.Semantic proximity Read ↗

The third activity for lysyl hydroxylase 3: galactosylation of hydroxylysyl residues in collagens in vitro.Semantic proximity Read ↗

Lysyl hydroxylase 3 modifies lysine residues to facilitate oligomerization of mannan-binding lectin.Semantic proximity Read ↗

Lysyl hydroxylase 3 is a multifunctional protein possessing collagen glucosyltransferase activity.Semantic proximity Read ↗

Re-evaluation of lysyl hydroxylation in the collagen triple helix: lysyl hydroxylase 1 and prolyl 3-hydroxylase 3 have site-differential and collagen type-dependent roles in lysine hydroxylationSemantic proximity Read ↗

A connective tissue disorder caused by mutations of the lysyl hydroxylase 3 gene.Semantic proximity Read ↗

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