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Article

Dysfunction of p53 pathway in human colorectal cancer: analysis of p53 gene mutation and the expression of the p53-associated factors p14ARF, p33ING1, p21WAF1 and MDM2.

International journal of oncology - 1 Oct 2004

Tachibana Masatsugu, Kawamata Hitoshi, Fujimori Takahiro, Omotehara Fumie, Horiuchi Hideki, Ohkura Yasuo, Igarashi Seiji, Kotake Kenjiro, Kubota Keiichi

Abstract excerpt

Mutations of p53 tumor suppressor gene increase with tumor progression in colorectal cancers. In this study, we examined the expressions of p33ING1, p14ARF, MDM2 and p21WAF1 mRNA in 25 advanced colorectal cancers by quantitative RT-PCR method, and compared the expression levels of p33ING1, p14ARF...

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Share to Cell Cycle Proteins
Share to Cyclin-Dependent Kinase Inhibitor p21

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, p53

Share to Genes, Tumor Suppressor

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Share to Proto-Oncogene Proteins c-mdm2

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Source

Identifiers

PMID: 15375540

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15375540-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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