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Article

Functional analysis of a zebrafish myd88 mutant identifies key transcriptional components of the innate immune system.

Disease models & mechanisms - 1 May 2013

van der Vaart Michiel, van Soest Joost J, Spaink Herman P, Meijer Annemarie H

Abstract excerpt

Toll-like receptors (TLRs) are an important class of pattern recognition receptors (PRRs) that recognize microbial and danger signals. Their downstream signaling upon ligand binding is vital for initiation of the innate immune response. In human and mammalian models, myeloid differentiation factor 88 (MYD88) is known for its central role as an adaptor molecule in interleukin 1 receptor (IL-1R) and TLR signaling....

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Source

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Identifiers

PMID: 23471913
DOI: 10.1242/dmm.010843
PMCID: PMC3634667

Genes

MYD88

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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