Article
Genetic mapping in mice identifies DMBT1 as a candidate modifier of mammary tumors and breast cancer risk.
The American journal of pathology - 1 Jun 2007
Blackburn Anneke C, Hill Linda Z, Roberts Amy L, Wang Jun, Aud Dee, Jung Jimmy, Nikolcheva Tania, Allard John, Peltz Gary, Otis Christopher N, Cao Qing J, Ricketts Reva St J, Naber Stephen P, Mollenhauer Jan, Poustka Annemarie, Malamud Daniel, Jerry D Joseph
Abstract excerpt
Low-penetrance breast cancer susceptibility alleles seem to play a significant role in breast cancer risk but are difficult to identify in human cohorts. A genetic screen of 176 N2 backcross progeny of two Trp53(+/-) strains, BALB/c and C57BL/6, which differ in their susceptibility to mammary tum...
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