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Dithiolethiones for cancer chemoprevention: where do we stand?

1 Nov 2008

Abstract excerpt

Dithiolethiones are a well-known class of cancer chemopreventive agents; the key mechanism of action of dithiolethiones involves activation of Nrf2 signaling and induction of phase II enzymes. In the past, attention has been focused mainly on 4-methyl-5-pyrazinyl-3H-1,2-dithiole-3-thione (oltipraz), which showed ability as a wide-spectrum inhibitor of chemical carcinogenesis in preclinical models. However,...

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PMID: 19001432
DOI: 10.1158/1535-7163.mct-08-0625

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