Article
HCV quasispecies evolution: association with progression to end-stage liver disease in hemophiliacs infected with HCV or HCV/HIV.
Blood - 15 Jan 2005
Qin Hongxing, Shire Norah J, Keenan Erica D, Rouster Susan D, Eyster M Elaine, Goedert James J, Koziel Margaret James, Sherman Kenneth E
Abstract excerpt
Patients with inherited bleeding disorders who received clotting factor concentrates before 1987 have high rates of hepatitis C virus (HCV) or HCV/HIV infection. We evaluated HCV quasispecies evolution in longitudinally collected specimens comparing those from patients with progression to end-stage liver disease (ESLD; cases) to those with compensated chronic hepatitis (controls). Plasma samples were obtained...
Topics
- Amino Acid Sequence
- Cohort Studies
- Disease Progression
- Evolution, Molecular
- Genetic Variation
- HIV Infections
- Hemophilia A
- Hepacivirus
- Hepatitis C, Chronic
- Humans
- Liver Failure
- Longitudinal Studies
- Molecular Sequence Data