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Article

Progression to end-stage liver disease in patients with inherited bleeding disorders and hepatitis C: an international, multicenter cohort study.

Blood - 1 May 2007

Posthouwer Dirk, Makris Michael, Yee Thynn T, Fischer Kathelijn, van Veen Joost J, Griffioen Anja, van Erpecum Karel J, Mauser-Bunschoten Eveline P

Abstract excerpt

Prior to 1990, many patients with inherited bleeding disorders were infected with hepatitis C virus (HCV). This study assessed the risk of end-stage liver disease (ESLD) in patients with hemophilia with chronic hepatitis C. Patients were infected between 1961 and 1990 and were followed up to August 2005. Of 847 anti-HCV(+) patients, 160 (19%) spontaneously cleared HCV and 687 (81%) developed chronic hepatitis C....

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PMID: 17213288
DOI: 10.1182/blood-2006-08-038349

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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